Seasonal allergic rhinitis affects sinonasal microbiota.
Identifieur interne : 000188 ( Main/Exploration ); précédent : 000187; suivant : 000189Seasonal allergic rhinitis affects sinonasal microbiota.
Auteurs : Chris H. Choi [États-Unis] ; Valeriy Poroyko ; So Watanabe ; Duo Jiang ; James Lane ; Marcella Detineo ; Fuad M. Baroody ; Robert M. Naclerio ; Jayant M. PintoSource :
- American journal of rhinology & allergy [ 1945-8932 ]
Descripteurs français
- KwdFr :
- MESH :
- isolement et purification : Bactéries.
- microbiologie : Muqueuse nasale, Rhinite allergique saisonnière.
- Adolescent, Adulte, Femelle, Humains, Microbiote, Mâle.
English descriptors
- KwdEn :
- MESH :
- isolation & purification : Bacteria.
- microbiology : Nasal Mucosa, Rhinitis, Allergic, Seasonal.
- Adolescent, Adult, Female, Humans, Male, Microbiota.
Abstract
BACKGROUND
Microbes and allergens can stimulate the nasal mucosa, potentially leading to the development of acute bacterial rhinosinusitis (ABRS). This study was designed to determine if allergen exposure alters the sinonasal microbiome.
METHODS
We performed a parallel observational study of healthy adults with seasonal allergic rhinitis (SAR; grass or tree, n = 20) or nonallergic subjects (n = 19). Microbiota specimens were obtained by endoscopy from the middle meatus and vestibule before and during the relevant season and were analyzed by terminal restriction fragment length polymorphism analysis. Differences in bacterial microbiota were assessed by standard ecological measures of bacterial diversity. Quality of life and symptom scores were recorded, and nasal lavages for eosinophils were performed.
RESULTS
SAR subjects had increased nasal symptoms in season, impaired disease-specific quality of life, and increased nasal eosinophils, compared with no changes in nonallergic subjects. During the season, SAR subjects had a significantly greater variety of organisms in the middle meatus compared with nonallergic subjects (p < 0.036) and increased bacterial diversity (Shannon index, p < 0.013). We found a significant positive correlation between bacterial diversity in the middle meatus during the season and the nasal lavage eosinophil count of SAR subjects. There were no significant changes in the nasal vestibule (p > 0.05, all comparisons).
CONCLUSION
The interaction of allergy and microbiota may affect the sinonasal physiology, with broad implications for several airway diseases. Characterization of the specific organisms involved using next-generation sequencing may clarify the relationship between allergic inflammation and ABRS. This finding may help explain why allergic inflammation predisposes to ABRS.
DOI: 10.2500/ajra.2014.28.4050
PubMed: 25197913
PubMed Central: PMC4101129
Affiliations:
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Choi</name><affiliation wicri:level="2"><nlm:affiliation>Section of Otolaryngologty-Head and Neck Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section of Otolaryngologty-Head and Neck Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Poroyko, Valeriy" sort="Poroyko, Valeriy" uniqKey="Poroyko V" first="Valeriy" last="Poroyko">Valeriy Poroyko</name></author><author><name sortKey="Watanabe, So" sort="Watanabe, So" uniqKey="Watanabe S" first="So" last="Watanabe">So Watanabe</name></author><author><name sortKey="Jiang, Duo" sort="Jiang, Duo" uniqKey="Jiang D" first="Duo" last="Jiang">Duo Jiang</name></author><author><name sortKey="Lane, James" sort="Lane, James" uniqKey="Lane J" first="James" last="Lane">James Lane</name></author><author><name sortKey="Detineo, Marcella" sort="Detineo, Marcella" uniqKey="Detineo M" first="Marcella" last="Detineo">Marcella Detineo</name></author><author><name sortKey="Baroody, Fuad M" sort="Baroody, Fuad M" uniqKey="Baroody F" first="Fuad M" last="Baroody">Fuad M. Baroody</name></author><author><name sortKey="Naclerio, Robert M" sort="Naclerio, Robert M" uniqKey="Naclerio R" first="Robert M" last="Naclerio">Robert M. Naclerio</name></author><author><name sortKey="Pinto, Jayant M" sort="Pinto, Jayant M" uniqKey="Pinto J" first="Jayant M" last="Pinto">Jayant M. 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Choi</name><affiliation wicri:level="2"><nlm:affiliation>Section of Otolaryngologty-Head and Neck Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section of Otolaryngologty-Head and Neck Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Poroyko, Valeriy" sort="Poroyko, Valeriy" uniqKey="Poroyko V" first="Valeriy" last="Poroyko">Valeriy Poroyko</name></author><author><name sortKey="Watanabe, So" sort="Watanabe, So" uniqKey="Watanabe S" first="So" last="Watanabe">So Watanabe</name></author><author><name sortKey="Jiang, Duo" sort="Jiang, Duo" uniqKey="Jiang D" first="Duo" last="Jiang">Duo Jiang</name></author><author><name sortKey="Lane, James" sort="Lane, James" uniqKey="Lane J" first="James" last="Lane">James Lane</name></author><author><name sortKey="Detineo, Marcella" sort="Detineo, Marcella" uniqKey="Detineo M" first="Marcella" last="Detineo">Marcella Detineo</name></author><author><name sortKey="Baroody, Fuad M" sort="Baroody, Fuad M" uniqKey="Baroody F" first="Fuad M" last="Baroody">Fuad M. Baroody</name></author><author><name sortKey="Naclerio, Robert M" sort="Naclerio, Robert M" uniqKey="Naclerio R" first="Robert M" last="Naclerio">Robert M. Naclerio</name></author><author><name sortKey="Pinto, Jayant M" sort="Pinto, Jayant M" uniqKey="Pinto J" first="Jayant M" last="Pinto">Jayant M. Pinto</name></author></analytic><series><title level="j">American journal of rhinology & allergy</title><idno type="eISSN">1945-8932</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Bacteria (isolation & purification)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Microbiota (MeSH)</term><term>Nasal Mucosa (microbiology)</term><term>Rhinitis, Allergic, Seasonal (microbiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Bactéries (isolement et purification)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Microbiote (MeSH)</term><term>Muqueuse nasale (microbiologie)</term><term>Mâle (MeSH)</term><term>Rhinite allergique saisonnière (microbiologie)</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Bacteria</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Bactéries</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Muqueuse nasale</term><term>Rhinite allergique saisonnière</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Nasal Mucosa</term><term>Rhinitis, Allergic, Seasonal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Microbiota</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Femelle</term><term>Humains</term><term>Microbiote</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Microbes and allergens can stimulate the nasal mucosa, potentially leading to the development of acute bacterial rhinosinusitis (ABRS). This study was designed to determine if allergen exposure alters the sinonasal microbiome.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We performed a parallel observational study of healthy adults with seasonal allergic rhinitis (SAR; grass or tree, n = 20) or nonallergic subjects (n = 19). Microbiota specimens were obtained by endoscopy from the middle meatus and vestibule before and during the relevant season and were analyzed by terminal restriction fragment length polymorphism analysis. Differences in bacterial microbiota were assessed by standard ecological measures of bacterial diversity. Quality of life and symptom scores were recorded, and nasal lavages for eosinophils were performed.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>SAR subjects had increased nasal symptoms in season, impaired disease-specific quality of life, and increased nasal eosinophils, compared with no changes in nonallergic subjects. During the season, SAR subjects had a significantly greater variety of organisms in the middle meatus compared with nonallergic subjects (p < 0.036) and increased bacterial diversity (Shannon index, p < 0.013). We found a significant positive correlation between bacterial diversity in the middle meatus during the season and the nasal lavage eosinophil count of SAR subjects. There were no significant changes in the nasal vestibule (p > 0.05, all comparisons).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>The interaction of allergy and microbiota may affect the sinonasal physiology, with broad implications for several airway diseases. Characterization of the specific organisms involved using next-generation sequencing may clarify the relationship between allergic inflammation and ABRS. This finding may help explain why allergic inflammation predisposes to ABRS.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25197913</PMID><DateCompleted><Year>2015</Year><Month>06</Month><Day>16</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1945-8932</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>4</Issue><PubDate><MedlineDate>2014 Jul-Aug</MedlineDate></PubDate></JournalIssue><Title>American journal of rhinology & allergy</Title><ISOAbbreviation>Am J Rhinol Allergy</ISOAbbreviation></Journal><ArticleTitle>Seasonal allergic rhinitis affects sinonasal microbiota.</ArticleTitle><Pagination><MedlinePgn>281-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2500/ajra.2014.28.4050</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Microbes and allergens can stimulate the nasal mucosa, potentially leading to the development of acute bacterial rhinosinusitis (ABRS). This study was designed to determine if allergen exposure alters the sinonasal microbiome.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We performed a parallel observational study of healthy adults with seasonal allergic rhinitis (SAR; grass or tree, n = 20) or nonallergic subjects (n = 19). Microbiota specimens were obtained by endoscopy from the middle meatus and vestibule before and during the relevant season and were analyzed by terminal restriction fragment length polymorphism analysis. Differences in bacterial microbiota were assessed by standard ecological measures of bacterial diversity. Quality of life and symptom scores were recorded, and nasal lavages for eosinophils were performed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">SAR subjects had increased nasal symptoms in season, impaired disease-specific quality of life, and increased nasal eosinophils, compared with no changes in nonallergic subjects. During the season, SAR subjects had a significantly greater variety of organisms in the middle meatus compared with nonallergic subjects (p < 0.036) and increased bacterial diversity (Shannon index, p < 0.013). We found a significant positive correlation between bacterial diversity in the middle meatus during the season and the nasal lavage eosinophil count of SAR subjects. There were no significant changes in the nasal vestibule (p > 0.05, all comparisons).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The interaction of allergy and microbiota may affect the sinonasal physiology, with broad implications for several airway diseases. Characterization of the specific organisms involved using next-generation sequencing may clarify the relationship between allergic inflammation and ABRS. This finding may help explain why allergic inflammation predisposes to ABRS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Choi</LastName><ForeName>Chris H</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Section of Otolaryngologty-Head and Neck Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, Illinois, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poroyko</LastName><ForeName>Valeriy</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Watanabe</LastName><ForeName>So</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Duo</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Lane</LastName><ForeName>James</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>deTineo</LastName><ForeName>Marcella</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Baroody</LastName><ForeName>Fuad M</ForeName><Initials>FM</Initials></Author><Author ValidYN="Y"><LastName>Naclerio</LastName><ForeName>Robert M</ForeName><Initials>RM</Initials></Author><Author ValidYN="Y"><LastName>Pinto</LastName><ForeName>Jayant M</ForeName><Initials>JM</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>UL1 TR000430</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 RR024999</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P20 AG012857</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 AG012857</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U19 AI106683</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 AI099713</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>KL2 RR025000</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K23 AG036762</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Rhinol Allergy</MedlineTA><NlmUniqueID>101490775</NlmUniqueID><ISSNLinking>1945-8932</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001419" MajorTopicYN="N">Bacteria</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064307" MajorTopicYN="Y">Microbiota</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009297" MajorTopicYN="N">Nasal Mucosa</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006255" MajorTopicYN="N">Rhinitis, Allergic, Seasonal</DescriptorName><QualifierName UI="Q000382" 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Baroody</name><name sortKey="Detineo, Marcella" sort="Detineo, Marcella" uniqKey="Detineo M" first="Marcella" last="Detineo">Marcella Detineo</name><name sortKey="Jiang, Duo" sort="Jiang, Duo" uniqKey="Jiang D" first="Duo" last="Jiang">Duo Jiang</name><name sortKey="Lane, James" sort="Lane, James" uniqKey="Lane J" first="James" last="Lane">James Lane</name><name sortKey="Naclerio, Robert M" sort="Naclerio, Robert M" uniqKey="Naclerio R" first="Robert M" last="Naclerio">Robert M. Naclerio</name><name sortKey="Pinto, Jayant M" sort="Pinto, Jayant M" uniqKey="Pinto J" first="Jayant M" last="Pinto">Jayant M. Pinto</name><name sortKey="Poroyko, Valeriy" sort="Poroyko, Valeriy" uniqKey="Poroyko V" first="Valeriy" last="Poroyko">Valeriy Poroyko</name><name sortKey="Watanabe, So" sort="Watanabe, So" uniqKey="Watanabe S" first="So" last="Watanabe">So Watanabe</name></noCountry><country name="États-Unis"><region name="Illinois"><name sortKey="Choi, Chris H" sort="Choi, Chris H" uniqKey="Choi C" first="Chris H" last="Choi">Chris H. Choi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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